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On the Medal begin with this prayer

O God, who gave to Saint Peregrine an angel for his companion, the Mother of God for his teacher, and Jesus as the physician of his malady, grant we beseech You through his merits that we may on Earth intensely love our holy angel, the Blessed Virgin Mary, and our Savior, and in Him bless them forever. Grant that we may receive the favor which we now petition. We ask this through the same Christ our Lord. Amen.

On the beads pray:

The Our Father on each bead in the first group of seven beads

Our Father, Who art in Heaven, Hallowed be Thy name.  Thy Kingdom come, Thy will be done on Earth as it is in Heaven.  Give us this day our daily bread, and forgive us our trespasses, as we forgive those who trespass against us, and lead us not into temptation, but deliver us from evil.   Amen.

The Hail Mary on each bead in the second group of seven beads

Hail Mary, full of grace, the Lord is with Thee.  Blessed art Thou among women and blessed is the fruit of Thy womb, Jesus.  Holy Mary, Mother of God, pray for us sinners now and at the hour of our death.  Amen.

The Glory Be on each bead in the third group of seven beads

Glory Be to the Father, and to the Son, and to the Holy Spirit.  As it was in the beginning, is now and ever shall be; World without end.  Amen.

Followed by the Saint Peregrine invocation

Saint Peregrine, pray for us.